The incidence and clinical predictors of ACE-inhibitor induced dry cough by perindopril in 27,492 patients with vascular disease
Identifieur interne : 003F27 ( Main/Exploration ); précédent : 003F26; suivant : 003F28The incidence and clinical predictors of ACE-inhibitor induced dry cough by perindopril in 27,492 patients with vascular disease
Auteurs : J. J. Brugts [Pays-Bas] ; Hisatomi Arima [Australie] ; W. Remme [Pays-Bas] ; M. Bertrand [France] ; R. Ferrari [Italie] ; K. Fox [Royaume-Uni] ; J. Dinicolantonio [États-Unis] ; S. Macmahon [Australie] ; J. Chalmers [Australie] ; F. Zijlstra [Pays-Bas] ; K. Caliskan [Pays-Bas] ; M. L. Simoons [Pays-Bas] ; J. J. Mourad [France] ; E. Boersma [Pays-Bas] ; K. M. Akkerhuis [Pays-Bas]Source :
- International journal of cardiology [ 0167-5273 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Objectives: Our objective was to investigate the actual incidence and clinical determinants of cough leading to discontinuation of ACE-inhibitors. Cough is the most frequent reason to stop ACE-inhibitor treatment. Methods: We studied 27,492 ACE-inhibitor naïve patients randomized to the ACE-inhibitor perindopril or placebo using individual data of 3 clinical trials. Multivariate logistic regression analysis was used to study the incidence of cough in relation to baseline clinical characteristics including racial background. Results: In 27,492 patients with cardiovascular disease, 1076 patients discontinued ACE-inhibitor perindopril due to cough (3.9%), 703 patients during run-in period of 4 weeks and 373 patients during a mean four years of follow-up. Significant determinants of cough were female gender (OR 1.92 95% CI 1.68-2.18), age above 65 years (OR 1.53 95% CI 1.35-1.73), and concomitant use of lipid-lowering agents (OR 1.37; 95% CI 1.18- 1.59). A simple clinical risk score composed of these 3 predictors of cough mounted to an odds ratio of 4.4 (95% CI 3.1-5.4) in the subjects with highest score (i.e. all determinants present). Racial background was not related to a differential incidence of cough in patients of Caucasian or Asian descendent (OR 1.11 95% CI 0.92-1.39). Conclusion: This large combined analysis of randomized clinical trials in 27,492 patients showed an overall lower incidence of cough leading to discontinuation of ACE-inhibitors (3.9%) as compared to literature. Clinical determinants of such cough are older age, female gender and concomitant use of lipid-lowering agents. In contrast, racial differences were not related to the incidence of cough.
Affiliations:
- Australie, France, Italie, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Hauts-de-France, Hollande-Méridionale, Nord-Pas-de-Calais, Nouvelle-Galles du Sud, Île-de-France
- Bobigny, Lille, Londres, Rotterdam, Sydney
- Université de Sydney
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Zijlstra</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Cardiology, Erasmus University Medical Center, Thoraxcenter</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Caliskan, K" sort="Caliskan, K" uniqKey="Caliskan K" first="K." last="Caliskan">K. 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Mourad</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Internal Medicine and Arterial Hypertension, CHJ Avicenne, APHP</s1><s2>Bobigny</s2><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Boersma, E" sort="Boersma, E" uniqKey="Boersma E" first="E." last="Boersma">E. Boersma</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Cardiology, Erasmus University Medical Center, Thoraxcenter</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Akkerhuis, K M" sort="Akkerhuis, K M" uniqKey="Akkerhuis K" first="K. M." last="Akkerhuis">K. M. Akkerhuis</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Cardiology, Erasmus University Medical Center, Thoraxcenter</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">15-0003951</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 15-0003951 INIST</idno><idno type="RBID">Pascal:15-0003951</idno><idno type="wicri:Area/PascalFrancis/Corpus">000149</idno><idno type="wicri:Area/PascalFrancis/Curation">005D04</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000056</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000056</idno><idno type="wicri:doubleKey">0167-5273:2014:Brugts J:the:incidence:and</idno><idno type="wicri:Area/Main/Merge">003F80</idno><idno type="wicri:Area/Main/Curation">003F27</idno><idno type="wicri:Area/Main/Exploration">003F27</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The incidence and clinical predictors of ACE-inhibitor induced dry cough by perindopril in 27,492 patients with vascular disease</title><author><name sortKey="Brugts, J J" sort="Brugts, J J" uniqKey="Brugts J" first="J. J." last="Brugts">J. J. Brugts</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Cardiology, Erasmus University Medical Center, Thoraxcenter</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The George Institute for Global Health, The Royal Prince Alfred Hospital</s1><s2>Sydney, NSW</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>The George Institute for Global Health, The University of Sydney</s1><s2>Sydney, NSW</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Remme, W" sort="Remme, W" uniqKey="Remme W" first="W." last="Remme">W. Remme</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>STICARES Cardiovascular Research Institute</s1><s2>Rhoon</s2><s3>NLD</s3><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>STICARES Cardiovascular Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Bertrand, M" sort="Bertrand, M" uniqKey="Bertrand M" first="M." last="Bertrand">M. Bertrand</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Lille Heart Institute</s1><s2>Lille</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Ferrari, R" sort="Ferrari, R" uniqKey="Ferrari R" first="R." last="Ferrari">R. Ferrari</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Cardiology, University of Ferrara, Salvatore Maugeri Foundation, IRCCS</s1><s2>Ferrara</s2><s3>ITA</s3><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Fox, K" sort="Fox, K" uniqKey="Fox K" first="K." last="Fox">K. Fox</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>NHLI, Imperial College, ICMS, Royal Brompton Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Dinicolantonio, J" sort="Dinicolantonio, J" uniqKey="Dinicolantonio J" first="J." last="Dinicolantonio">J. Dinicolantonio</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Mid-America Heart Institute, Saint Luke's Hospital</s1><s2>KS City, MO</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>KS City, MO</wicri:noRegion></affiliation></author><author><name sortKey="Macmahon, S" sort="Macmahon, S" uniqKey="Macmahon S" first="S." last="Macmahon">S. Macmahon</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The George Institute for Global Health, The Royal Prince Alfred Hospital</s1><s2>Sydney, NSW</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>The George Institute for Global Health, The University of Sydney</s1><s2>Sydney, NSW</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The George Institute for Global Health, The Royal Prince Alfred Hospital</s1><s2>Sydney, NSW</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>The George Institute for Global Health, The University of Sydney</s1><s2>Sydney, NSW</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Zijlstra, F" sort="Zijlstra, F" uniqKey="Zijlstra F" first="F." last="Zijlstra">F. Zijlstra</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Cardiology, Erasmus University Medical Center, Thoraxcenter</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Caliskan, K" sort="Caliskan, K" uniqKey="Caliskan K" first="K." last="Caliskan">K. Caliskan</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Cardiology, Erasmus University Medical Center, Thoraxcenter</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Simoons, M L" sort="Simoons, M L" uniqKey="Simoons M" first="M. L" last="Simoons">M. L. Simoons</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Cardiology, Erasmus University Medical Center, Thoraxcenter</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Mourad, J J" sort="Mourad, J J" uniqKey="Mourad J" first="J. J." last="Mourad">J. J. Mourad</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Internal Medicine and Arterial Hypertension, CHJ Avicenne, APHP</s1><s2>Bobigny</s2><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Boersma, E" sort="Boersma, E" uniqKey="Boersma E" first="E." last="Boersma">E. Boersma</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Cardiology, Erasmus University Medical Center, Thoraxcenter</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Akkerhuis, K M" sort="Akkerhuis, K M" uniqKey="Akkerhuis K" first="K. M." last="Akkerhuis">K. M. Akkerhuis</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Cardiology, Erasmus University Medical Center, Thoraxcenter</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j" type="main">International journal of cardiology</title><title level="j" type="abbreviated">Int. j. cardiol.</title><idno type="ISSN">0167-5273</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International journal of cardiology</title><title level="j" type="abbreviated">Int. j. cardiol.</title><idno type="ISSN">0167-5273</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ACE inhibitor</term><term>Antihypertensive agent</term><term>Cardiology</term><term>Cardiovascular disease</term><term>Dry</term><term>Human</term><term>Incidence</term><term>Induced cough</term><term>Intolerance</term><term>Patient</term><term>Perindopril</term><term>Prediction</term><term>Predictive factor</term><term>Predictor</term><term>Vascular disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie des vaisseaux sanguins</term><term>Pathologie de l'appareil circulatoire</term><term>Incidence</term><term>Prédicteur</term><term>Facteur prédictif</term><term>Prédiction</term><term>Inhibiteur angiotensin converting enzyme</term><term>Toux provoquée</term><term>A sec</term><term>Périndopril</term><term>Homme</term><term>Malade</term><term>Intolérance</term><term>Cardiologie</term><term>Antihypertenseur</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: Our objective was to investigate the actual incidence and clinical determinants of cough leading to discontinuation of ACE-inhibitors. Cough is the most frequent reason to stop ACE-inhibitor treatment. Methods: We studied 27,492 ACE-inhibitor naïve patients randomized to the ACE-inhibitor perindopril or placebo using individual data of 3 clinical trials. Multivariate logistic regression analysis was used to study the incidence of cough in relation to baseline clinical characteristics including racial background. Results: In 27,492 patients with cardiovascular disease, 1076 patients discontinued ACE-inhibitor perindopril due to cough (3.9%), 703 patients during run-in period of 4 weeks and 373 patients during a mean four years of follow-up. Significant determinants of cough were female gender (OR 1.92 95% CI 1.68-2.18), age above 65 years (OR 1.53 95% CI 1.35-1.73), and concomitant use of lipid-lowering agents (OR 1.37; 95% CI 1.18- 1.59). A simple clinical risk score composed of these 3 predictors of cough mounted to an odds ratio of 4.4 (95% CI 3.1-5.4) in the subjects with highest score (i.e. all determinants present). Racial background was not related to a differential incidence of cough in patients of Caucasian or Asian descendent (OR 1.11 95% CI 0.92-1.39). Conclusion: This large combined analysis of randomized clinical trials in 27,492 patients showed an overall lower incidence of cough leading to discontinuation of ACE-inhibitors (3.9%) as compared to literature. Clinical determinants of such cough are older age, female gender and concomitant use of lipid-lowering agents. In contrast, racial differences were not related to the incidence of cough.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Hauts-de-France</li><li>Hollande-Méridionale</li><li>Nord-Pas-de-Calais</li><li>Nouvelle-Galles du Sud</li><li>Île-de-France</li></region><settlement><li>Bobigny</li><li>Lille</li><li>Londres</li><li>Rotterdam</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Brugts, J J" sort="Brugts, J J" uniqKey="Brugts J" first="J. J." last="Brugts">J. J. Brugts</name></region><name sortKey="Akkerhuis, K M" sort="Akkerhuis, K M" uniqKey="Akkerhuis K" first="K. M." last="Akkerhuis">K. M. Akkerhuis</name><name sortKey="Boersma, E" sort="Boersma, E" uniqKey="Boersma E" first="E." last="Boersma">E. Boersma</name><name sortKey="Caliskan, K" sort="Caliskan, K" uniqKey="Caliskan K" first="K." last="Caliskan">K. Caliskan</name><name sortKey="Remme, W" sort="Remme, W" uniqKey="Remme W" first="W." last="Remme">W. Remme</name><name sortKey="Simoons, M L" sort="Simoons, M L" uniqKey="Simoons M" first="M. L" last="Simoons">M. L. Simoons</name><name sortKey="Zijlstra, F" sort="Zijlstra, F" uniqKey="Zijlstra F" first="F." last="Zijlstra">F. Zijlstra</name></country><country name="Australie"><noRegion><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name></noRegion><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><name sortKey="Macmahon, S" sort="Macmahon, S" uniqKey="Macmahon S" first="S." last="Macmahon">S. Macmahon</name><name sortKey="Macmahon, S" sort="Macmahon, S" uniqKey="Macmahon S" first="S." last="Macmahon">S. Macmahon</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Bertrand, M" sort="Bertrand, M" uniqKey="Bertrand M" first="M." last="Bertrand">M. Bertrand</name></region><name sortKey="Mourad, J J" sort="Mourad, J J" uniqKey="Mourad J" first="J. J." last="Mourad">J. J. Mourad</name></country><country name="Italie"><noRegion><name sortKey="Ferrari, R" sort="Ferrari, R" uniqKey="Ferrari R" first="R." last="Ferrari">R. Ferrari</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Fox, K" sort="Fox, K" uniqKey="Fox K" first="K." last="Fox">K. Fox</name></region></country><country name="États-Unis"><noRegion><name sortKey="Dinicolantonio, J" sort="Dinicolantonio, J" uniqKey="Dinicolantonio J" first="J." last="Dinicolantonio">J. Dinicolantonio</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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